...
WE INVEST IN FOUNDERS IMPACTING HISTORY
We believe in Khosla's Instigator Hypothesis: individuals scaling world-changing technology will solve the largest problems in the world. For example, 12-15 entrepreneurs creating the right companies is all it will take to solve the climate crisis.
We are a research-driven venture capital firm that invests as early as possible into the “best ideas in impact.” Too much of venture capital has gone into “backyard problems” rather than the grand global challenges.
We exist to fund and support founders working on the hardest problems in the world.
We are the earliest investors in mission-driven founders until their companies are attractive to top-tier VCs. In our Fund I, we have a 69% rate of follow-on investment by top-tier firms and a 100% follow-on rate overall.
AS OF Q2 2025
Our investments
Totus Medicines
Platform to rapidly design covalent drugs and cure new illnesses.
We invested
Pre-Seed
Last round
Series B led by DCVC Bio
Menten AI
Generative AI platform to design cell-permeable peptides that can attach to 60% of undruggable targets.
We invested
Seed
Catena Biosciences
Novel protein conjugation to create breakthroughs biological therapeutics.
We invested
Seed
Voyage Foods
Future-proofing your favorite food and drink.
We invested
Seed
Last round
Series A led by Horizons
Limelight Steel
Harnessing light to power zero-emissions steel manufacturing.
We invested
Pre-Seed
Last round
Seed led by Khosla
Charm Industrial
Converts waste biomass into fast pyrolysis, high carbon bio-oil.
We invested
Series A
Last round
Series B led by General Catalyst
WE AIM TO BE THE MOST COLLABORATIVE FUND IN THE WORLD.
Our team invests worldwide from NYC
We partner early. We are comfortable with the rough imperfections of start-ups. As a solo GP with 42+ venture partners, we are highly responsive but also have the broad-based experience to fully support world-changing entrepreneurs.
Plus 42 global venture partners that help founders bend the trajectory of success
Latest Press
Ag residue and carbon removal
Latitude Media September 25, 2025
Crop waste could fill old wells and sequester carbon
Axios September 23, 2025
A new life for old wells: startup injects bio-oil underground in Louisiana
Carbon Herald September 18, 2025
Prometheus slashes cost of carbon capture by more than 80%, unlocking affordable e-fuels as a new source of 24/7 carbon neutral power
Joplin Globe September 15, 2025
Greener steel through chemistry
Anthropocene Magazine September 9, 2025